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Skin and Eye Inflammation Due to Autoimmune Disorder (Uveodermatologic Syndrome) in Dogs

Uveodermatologic Syndrome in Dogs

Dogs’ immune systems produce antibodies to safeguard their bodies against harmful substances and organisms like viruses and bacteria. An autoimmune disorder arises when the immune system fails to distinguish between harmful antigens and the body’s healthy tissues, leading it to attack those tissues. Uveodermatologic syndrome is an autoimmune disorder known to affect dogs.

Certain breeds, such as Akitas, Samoyeds, and Siberian Huskies, are more prone to developing this disorder. However, dogs of all ages face the risk of its onset.


  • Inflammation of the inner eye (uvea)
  • Reduction of skin pigmentation (leukoderma) on the nose, lips, eyelids, footpads, scrotum, anus, and hard palate


Root autoimmune disorder


Following a comprehensive review of your dog’s medical history, your veterinarian will conduct a detailed physical and ophthalmological examination, considering the background of symptoms and potential incidents leading to the condition. Routine laboratory assessments will involve a blood chemical profile, complete blood count, urinalysis, and electrolyte panel. Typically, these tests yield normal results in animals affected by this disorder.

Additionally, your veterinarian will obtain skin tissue samples for laboratory analysis. A veterinary pathologist will microscopically examine the tissue sample to identify any characteristic changes associated with this condition.


Immediate intervention is crucial to prevent permanent damage to the eyes. Without prompt treatment, your dog may experience complications and potentially permanent blindness.

The primary goal of treatment is to suppress the abnormal immune response targeting healthy body tissues, particularly the eyes and skin. Upon conclusive diagnosis, your veterinarian will prescribe appropriate injections and eye drops for your dog.

Since immune system suppression can lead to complications, it’s essential to discuss this approach in detail with your veterinarian. Specific precautions must be taken to shield your dog from serious infections while undergoing immune system therapy.

Living and Management

Throughout the initial treatment phase, you may be required to visit your veterinarian twice weekly. During these appointments, your veterinarian will perform laboratory tests and eye examinations to track your dog’s progress and make medication adjustments as necessary. Regular adjustments to drug doses are essential to prevent complications commonly associated with immunosuppressive therapy.

Additionally, it’s important to monitor your dog’s overall health and promptly report any concerns to your veterinarian. Timely resolution of issues is crucial to prevent potential life-threatening situations.

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