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Cancerous Lymphoid Cells in the Lungs of Dogs

Lymphomatoid Granulomatosis in Dogs

Lymphomatoid granulomatosis is an uncommon illness observed in dogs characterized by the invasion of cancerous lymphoid cells, including lymphocytes and plasma cells, into the lungs. This condition can lead to metastasis in various body sites and organs such as the liver, heart, spleen, pancreas, and kidneys. While lymphomatoid granulomatosis doesn’t show breed or gender specificity, it tends to be more prevalent among large and purebred dogs.

Symptoms and Types

Symptoms associated with lymphomatoid granulomatosis typically involve respiratory distress that progresses over time. The following are among the most frequently observed signs of this condition:

  • Persistent cough
  • Labored breathing
  • Reduced ability to engage in physical activity
  • Weight loss (cachexia)
  • Loss of appetite (anorexia)
  • Occasional fever in affected animals


The precise cause of lymphomatoid granulomatosis remains unidentified at present.


To diagnose lymphomatoid granulomatosis in your dog, it’s crucial to provide your veterinarian with a detailed history of your dog’s health, including the onset and characteristics of the symptoms. Your veterinarian will conduct a comprehensive physical examination along with a series of tests including a biochemistry profile, urinalysis, and complete blood count. However, the results from these tests are typically nonspecific and inconsistent with the disease.

Blood analysis may indicate elevated levels of neutrophils, eosinophils, and basophils, which are various types of white blood cells. X-rays will offer insights into lung tissue and any abnormalities present. Additionally, your veterinarian may opt to perform a biopsy, extracting a small sample of lung tissue for further analysis by a veterinary pathologist to confirm the diagnosis definitively.


Regrettably, there is currently no cure for lymphomatoid granulomatosis in dogs. Nevertheless, a common approach involves combining chemotherapy with surgical removal of the affected tissue. Throughout the treatment process, regular blood tests and thorough evaluations of cardiac and other bodily systems are essential to monitor the progress and manage any potential complications.

Living and Management

Since there is no known cure, consulting a veterinary oncologist is advisable for the best course of action. Chemotherapy drugs can have significant toxicity on various bodily systems, leading to potential complications during and after treatment. If you notice any concerning symptoms in your dog such as difficulty breathing, lethargy, or loss of appetite, contact your veterinarian immediately. In cases of severe complications, your veterinarian may adjust dosages or discontinue treatment altogether. It’s important to note that chemotherapy medication poses potential risks to human health and should only be administered under the guidance of a veterinary oncologist and stored securely.

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